In the seminiferous tubule of the mammalian testis, one type A1 spermatogonium (diploid, 2n) divides and differentiates into 256 spermatozoa (haploid, n) during spermatogenesis. To complete spermatogenesis and produce ∼150 × 106 spermatozoa each day in a healthy man, germ cells must migrate progressively across the seminiferous epithelium yet remain attach to the nourishing Sertoli cells. This active cell migration process involves precisely controlled restructuring events at the tight (TJ) and anchoring junctions at the cell–cell interface. While the hormonal events (...) that regulate spermatogenesis by follicle‐stimulating hormone and testosterone from the pituitary gland and Leydig cells, respectively, are known, less is known about the mechanism(s) that regulates junction restructuring during germ cell movement in the seminiferous epithelium. The relative position of tight (TJs) and anchoring junctions in the testis is of interest. Sertoli cell TJs that constitute the blood–testis barrier (BTB) are present side by side with anchoring junctions and are adjacent to the basement membrane. This intimate physical association with the TJs, the anchoring junctions and the basement membrane (a modified form of extracellular matrix, ECM) suggests a role for the ECM in the junction dynamics of the testis. Indeed, evidence is accumulating that ECM proteins are crucial to Sertoli cell TJ dynamics. In this review, we discuss the pivotal role of tumor necrosis factor α (TNFα) on BTB dynamics via its effects on the homeostasis of ECM proteins. In addition, discussion will also be focused on the novel findings regarding the role of non‐basement‐membrane‐associated ECM proteins and components of focal adhesion (a cell–matrix anchoring junction type) in the regulation of junction dynamics in the testis. BioEssays 26:978–992, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Objectives: To study the attitudes of both medical and non-medical students towards the do-not-resuscitate decision in a university in Hong Kong, and the factors affecting their attitudes.Methods: A questionnaire-based survey conducted in the campus of a university in Hong Kong. Preferences and priorities of participants on cardiopulmonary resuscitation in various situations and case scenarios, experience of death and dying, prior knowledge of DNR and basic demographic data were evaluated.Results: A total of 766 students participated in the study. There were statistically (...) significant differences in their DNR decisions in various situations between medical and non-medical students, clinical and preclinical students, and between students who had previously experienced death and dying and those who had not. A prior knowledge of DNR significantly affected DNR decision, although 66.4% of non-medical students and 18.7% of medical students had never heard of DNR. 74% of participants from both medical and non-medical fields considered the patient’s own wish as the most important factor that the healthcare team should consider when making DNR decisions. Family wishes might not be decisive on the choice of DNR.Conclusions: Students in medical and non-medical fields held different views on DNR. A majority of participants considered the patient’s own wish as most important in DNR decisions. Family wishes were considered less important than the patient’s own wishes. (shrink)

The concept of rectifying names [cheng-ming] is a familiar one in the Confucian Analects. It occupies an important, if not central, position in the political philosophy of Confucius. Since, according to Confucius, the rectification of names is the basis of the establishment of social harmony and political order, one might suspect that later political theories of Confucian-ists should be traced back to the Confucian doctrine of rectifying names. It need not be added that the theory of rectifying names, as (...) developed by Hsün Tzu in the third century B. C., served the double purpose of strengthening his political doctrine of government on the one hand and repudiating doctrines of names on the other. (shrink)

Sudoku puzzles, which are popular worldwide, require individuals to infer the missing digits in a 9 9 array according to the general rule that every digit from 1 to 9 must occur once in each row, in each column, and in each of the 3-by-3 boxes in the array. We present a theory of how individuals solve these puzzles. It postulates that they rely solely on pure deductions, and that they spontaneously acquire various deductive tactics, which differ in their difficulty (...) depending on their “relational complexity”, i.e., the number of constraints on which they depend. A major strategic shift is necessary to acquire tactics for more difficult puzzles: solvers have to keep track of possible digits in a cell. We report three experiments corroborating this theory. We also discuss their implications for theories of reasoning that downplay the role of deduction in everyday reasoning. (shrink)

Here presented are three singular, philosophical perspectives on the Delhi student protests which took place in 2019 and 2020, before the coronavirus pandemic. The writers hail from India, England...

This compilation brings together 20 essays of Santiago Ramón y Cajal (1852-1934), the neuroscientist par excellence and 1906 Nobel Laureate in Medicine, on topics beyond neuroanatomy, most appearing in English for the first time. The annotated collection makes available in one handy volume Cajal's ideas on psychology, art and education, still current and still relevant, derived from his books La Psicología de los Artistas, Charlas de Café, El Mundo Visto a los Ochenta Años, Pensamientos Pedagógicos and Escritos Inéditos. An acute (...) observer of the intellectual and social scene of the avant-garde, Cajal emerged in 20th-century Spain in a further role as a philosopher and educator. The contents bespeak Cajal's inquiry into the varieties of human experience and shed new light on the breadth of his genius, imagination and passion, helping us to rethink what we thought we already understood about Don Santiago's own mind. (shrink)

Definición del derecho natural -- Definición del derecho de gentes -- Diferencia de otras ciencias -- Del derecho público -- De la política -- Necesidad y utilidad del derecho natural y de gentes -- Origen y antiguedad de este derecho -- Formación de esta ciencia -- Progresos y escritores principales. Hugo Grotius -- John Selden -- Thomas Hobbes -- Samuel Pufendorf -- Christian Thomasius -- Johann Gottlieb Heineccius -- Christian Wolff -- Emer de Vattel -- Jean-Jacques Burlamaqui. Fortunato Bartolomeo De (...) Felice -- Otros escritores en com un -- Montesquieu -- Simon-Nicolas-Henri Linguet -- Jean-Jacques Rousseau -- Escritos modernos detestables -- Vicios y defectos de muchos modernos -- Modo para conocer los autores sospechosos -- Autores católicos con que se refutan -- Precaución para establecer las reglas del derecho natural -- Falsa preocupaci on de buscar un primer principio -- Métodos que se proponen -- No son necesarios -- Del método escolástico -- Universidades en que se enseña este derecho. (shrink)

En 1868, impulsado por el krausismo, se introdujo en el Bachillerato español una nueva asignatura, la Antropología. Nicolás Salmerón que no fue ajeno a la novedad, comenzó a escribir un texto para ella sobre la base de las explicaciones de clase que él mismo impartía en su Colegio Internacional. Ese texto dio lugar al libro que nos ocupa que, aunque inédito e incompleto, permite ofrecer una visión filosófica más completa de su etapa juvenil. Su mérito estriba en haber articulado en (...) disciplina una de las materias clave de la filosofía krausista y ofrecer una idea global e integradora de lo que con el tiempo se llamaría Antropología filosófica. (shrink)

The medical ethics of a physician’s relationship with a prisoner who is participating in a collective hunger strike has become a major public, professional, and governmental concern in The Republic of Turkey. This article examines the Turkish experience and debate about physician ethics during prison hunger strikes. It is hoped that this analysis will be of use to those formulating policy in similar situations.

It is time for the noon conference. Your job is to impart a career-changing experience in ethics to a group of students and interns gathered from four different schools with varying curriculums in ethics. They have just finished 1½ h of didactic sessions and lunch. One third of them were on call last night. Your first job is to keep them awake. The authors argue that this “tragic case” approach to ethics education is of limited value because it limits understanding (...) of moral problems to dilemmas; negates the moral agency of the student; encourages solutions that are merely intellectual; and suggests that ethical encounters are a matter for experts. The authors propose an alternative that focuses on three issues: the provider-patient relationship, the relationships between providers in the everyday world of health work and, the social position of healthcare providers in society. In this approach, teachers are not experts but more like guides on a journey who help students to learn that much of ethical practice comprises living through difficult situations of caring for vulnerable others and who help students to navigate some of these difficulties. (shrink)

We give several characterizations of Schnorr trivial sets, including a new lowness notion for Schnorr triviality based on truth-table reducibility. These characterizations allow us to see not only that some natural classes of sets, including maximal sets, are composed entirely of Schnorr trivials, but also that the Schnorr trivial sets form an ideal in the truth-table degrees but not the weak truth-table degrees. This answers a question of Downey, Griffiths and LaForte.

Henrich et al. address how culture leads to cognitive variability and recommend that researchers be critical about the samples they investigate. However, there are other sources of variability, such as individual strategies in reasoning and the content and context on which processes operate. Because strategy and content drive variability, those factors are of primary interest, while culture is merely incidental.

A highly idiosyncratic search for universal laws governing the development of a feeling of well-being and creative involvement in life. Numerous, somewhat mystical, experiences are described with enthusiasm and candor, but, perhaps, uncertain significance for those less inclined toward mysticism.—N. Y.

We show that every countable ideal of degrees that are low for isomorphism is contained in a principal ideal of degrees that are low for isomorphism by adapting an exact pair construction. We further show that within the hyperimmune free degrees, lowness for isomorphism is entirely independent of computable traceability.

We show that van Lambalgen's Theorem fails with respect to recursive randomness and Schnorr randomness for some real in every high degree and provide a full characterization of the Turing degrees for which van Lambalgen's Theorem can fail with respect to Kurtz randomness. However, we also show that there is a recursively random real that is not Martin-Löf random for which van Lambalgen's Theorem holds with respect to recursive randomness.

We study the connection between Schnorr triviality and genericity. We show that while no 2-generic is Turing equivalent to a Schnorr trivial and no 1-generic is tt-equivalent to a Schnorr trivial, there is a 1-generic that is Turing equivalent to a Schnorr trivial. However, every such 1-generic must be high. As a corollary, we prove that not all K-trivials are Schnorr trivial. We also use these techniques to extend a previous result and show that the bases of cones of Schnorr (...) trivial Turing degrees are precisely those whose jumps are at least 0". (shrink)

Although performance pressure has desirable consequences, there is evidence that it can produce unintended outcomes as employees tend to engage in dysfunctional and unethical behaviors to meet performance goals. Thus, the process through which employees think and behave unethically under performance pressure deserves more research attention. This study goes beyond the stress-appraisal perspective and investigates whether and when performance pressure influences individual work mindsets and behaviors from a moral reasoning perspective. Specifically, we contend that performance pressure is related to employee (...) expediency through moral decoupling. We further hypothesize dialectical thinking and moral identity to be the boundary conditions of the proposed relationships. Analyses of data from a field study in three waves provide support for most of the hypotheses. In particular, we find that moral decoupling accounts for additional variance after we control for the stress-appraisal effect of performance pressure on employee expediency. The study offers several contributions to the literature on performance pressure and unethical behavior. (shrink)

We investigate the relationship between lowness for Schnorr randomness and Schnorr triviality. We show that a real is low for Schnorr randomness if and only if it is Schnorr trivial and hyperimmune free.

The weakly random reals contain not only the Schnorr random reals as a subclass but also the weakly 1-generic reals and therefore the n -generic reals for every n . While the class of Schnorr random reals does not overlap with any of these classes of generic reals, their degrees may. In this paper, we describe the extent to which this is possible for the Turing, weak truth-table, and truth-table degrees and then extend our analysis to the Schnorr random and (...) hyperimmune reals. (shrink)